A generic drug is an exact copy of the active drug in a brand-name medication. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs. Generics and biosimilars usually cost less than brand-name medications. Prolia costs significantly more than either brand-name Fosamax or its generic drug alendronate. It’s important to note that during clinical trials, one of the rare but serious side effects of Prolia was atypical femur fractures. Femur fractures can cause pain to your hip, groin, or thigh.
Your doctor will let you know whether you’ll need to take any other prescription medications with Prolia. There’s reese witherspoon fetal alcohol syndrome even a current ongoing study looking at whether Prolia may be effective in reversing bone damage that’s already happened due to RA. In addition to the uses listed above, Prolia may be used off-label. Off-label drug use is when a drug that’s approved for one use is used for a different use that’s not approved. After 1 year of treatment with Prolia, females taking Prolia had a spinal BMD that was 5.5% higher than females taking the placebo. People taking steroids for 3 months or longer who used Prolia also had a larger increase in their spinal BMD compared with people using risedronate.
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However, alcohol can increase your risk of both osteoporosis and bone fractures. This is because alcohol can affect how your body absorbs calcium, which your body needs in order to have strong, healthy bones. Another study, done in 2009, compared Prolia and Fosamax in treating osteoporosis in females who’d gone through menopause. In this study, the females’ bone mineral density (BMD) was measured.
However, individuals may have different responses to the drug, as Tmax ranges from 3 days to 21 days post-dose (with a median of 10 days). Drug concentration decreases maverick house sober living over 4 to 5 months post-dose. The following information is provided for clinicians and other healthcare professionals. If you’re pregnant or planning to become pregnant, talk with your doctor before starting Prolia.
And you should continue using birth control for at least 5 months after stopping Prolia. If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist. Prolia is not known to interact with other medications, herbs, supplements, foods, or alcohol. The manufacturer did not list any interactions in the drug’s prescribing information. But Prolia contains the active drug denosumab, while Evenity contains the active drug romosozumab-aqqg. Call your doctor right away if you have an allergic reaction to Prolia.
Prolia injection and birth control
Call your doctor for medical advice personalized sobriety gifts about side effects. If you receive Prolia, you should not receive Xgeva, Wyost, or Jubbonti. You should talk with your doctor if you develop any mild side effects that concern you. You should also talk with them if you have any serious side effects during Prolia treatment.
Atypical femur fractures are unusual fractures in your thigh. They’re usually not caused by major trauma to the area. And it’s even possible to have atypical femur fractures in both of your thighs at the same time. If you have any dental or jaw-related side effects, such as mouth pain or loosening of your teeth, see your dentist or doctor right away.
- Tell your healthcare provider if you have any of these side effects that bother you.
- In clinical trials, Prolia was effective in treating osteoporosis in males.
- And it’s even possible to have atypical femur fractures in both of your thighs at the same time.
- If you drink alcohol, talk with your doctor to see if there’s a safe amount of alcohol you can drink while you’re taking Prolia.
- Do not stop using this medicine without first talking to your doctor.
How Prolia injection works
And like generic drugs, biosimilars tend to cost less than brand-name medications. Note that this list is not all-inclusive and includes only common medications that may interact with Prolia. You should refer to the prescribing information for Prolia for a complete list of interactions. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does.
Related/similar drugs
They might also recommend physical therapy, massage therapy, or using a heating pad. If your pain becomes severe, your doctor may recommend other treatment options to replace Prolia. Bone pain from Prolia may be most noticeable in your arms and legs. Muscle pain often contributes to back pain, one of the most common side effects reported in clinical trials of Prolia. Hair loss wasn’t reported as a side effect during clinical trials of Prolia. But hair loss has been reported by people who have taken Prolia since then.
The drug attaches to the RANK protein and helps prevent osteoclasts from breaking down bone. Your doctor will recommend the dosage of Prolia that’s right for you. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Additionally, you may experience different side effects from those listed below based on the condition you’re treating with Prolia. Your side effects from Prolia may also vary depending on your biological sex. Jubbonti (denosumab-bbdz) is an interchangeable biosimilar to Prolia that was FDA-approved on 5 March 2024.
